He wrote the classic clinical text Zebra Cards: An Aid to Obscure Diagnoses, which catalogs unusual and striking manifestations of disease largely unknown to physicians.

In 2003 Dr. Sotos established that President William Howard Taft had severe obstructive sleep apnea during his Presidency. This was part of his larger work on an award-winning web encyclopedia of The Medical History of American Presidents. It has been the Yahoo! Site of the Day and has twice been a USA Today Hot Site.

Dr. Sotos is currently the CEO of Apneos Corporation, a chief flight surgeon in the Air National Guard, and a medical technical advisor for the television series House, MD.